This study was conducted in 1985 in Asuncion, Paraguay, 6 years after the closure of the state supported family planning services. Data from national surveys in 1977 and 1987 permit a comparison of sources of contraceptive supplies before and after the elimination of government support for family planning. The purchase of pseudo-abortifacients from private pharmacies was used as an indication of induced abortion. After the loss of government clinics, it is suggested that some women turned to pharmacists to obtain pseudo-abortifacients (...) when faced with unwanted pregnancy. There is an indication of increased pseudo-abortifacient use, particularly among unmarried women and those from poorer neighbourhoods. (shrink)

Philosophers have traditionally conceived of discovery in terms of internal cognitive acts. Close consideration of Rosalind Franklin's role in the discovery of the DNA double helix, however, reveals some problems with this traditional conception. This article argues that defining discovery in terms of mental operations entails problematic conclusions and excludes acts that should fall within the domain of discovery. It proposes that discovery be expanded to include external acts of making visible. Doing so allows for a reevaluation of Franklin's role (...) in the discovery of the structure of DNA. (shrink)

The opening sections of some exegetical Midrashim deal with the same type of material that is found in introductions to medieval rabbinic Bible commentaries. The application of Goldberg's form analysis to these sections reveals the new form "Inner-Midrashic Introduction" as a thematic discourse on introductory issues to biblical books. By its very nature the IMI is embedded within the comments on the first biblical verse. Further analysis of medieval rabbinic Bible commentary introductions in terms of their formal, thematic, and material (...) characteristics, reveals that a high degree of continuity exists between them and the IMIs, including another newly discovered form, the "Inner-Commentary Introduction". These new discoveries challenge the current view that traces the origin of Bible introduction in Judaism exclusively to non-Jewish models. They also point to another important link between the Midrashim and the commentaries, i.e., the decomposition of the functional form midrash in the new discoursive context of the commentaries. Finally, the form analysis demonstrates how larger discourses are formed in the exegetical Midrashim. (shrink)

The innovative field of Regenerative Medicine (RM) is expected to extend the possibilities of prevention or early treatment in healthcare. Increasingly, clinical trials will be developed for people at risk of disease to investigate these RM interventions. These individuals at risk are characterised by their susceptibility for developing clinically manifest disease in future due to the existence of degenerative abnormalities. So far, there has been little debate about the ethical appropriateness of including such individuals at risk in clinical trials. We (...) discuss three main challenges of selecting this participant model for testing RM interventions: the challenge of achieving a proportional risk–benefit balance; complexities in the trial design in terms of follow-up and sample size; and the difficulty of obtaining informed consent due to the many uncertainties. We conclude that selecting the model is not ethically justifiable for first-in-man trials with RM interventions due to the high risks and uncertainties. However, the model can be ethically appropriate for testing the efficacy of RM interventions under the following conditions: interventions should be low risk; the degenerative abnormalities (and other risk factors) should be strongly related with disease within a short time frame; robust preclinical evidence of efficacy needs to be present; and the informed consent procedure should contain extra safeguards with regard to communication on uncertainties. (shrink)

Individuals with anxiety disorders show deficits in the discrimination between a cue that predicts an aversive outcome and a safe stimulus that predicts the absence of that outcome. This impairment has been linked to increased spontaneous recovery of fear following extinction, however it is unknown if there is a link between discrimination and return of fear in a novel context. It is also unknown if impaired discrimination mediates the relationship between trait anxiety and either spontaneous recovery or context renewal. The (...) present study used a differential fear conditioning paradigm to examine the relationships between trait anxiety, discrimination learning, spontaneous recovery and context renewal in healthy volunteers. Fear learning was assessed using continuous ratings of US expectancy and subjective ratings of fear. Discrimination mediated the relationships between trait anxiety and both spontaneous recovery and context renewal such that elevated trait anxiety was associated with poorer discrimination, which in turn was associated with increased fear at test phases. Results are discussed in terms of the genesis and maintenance of anxiety disorders. (shrink)

Sound moves us. Nowhere is this more apparent than in our responses to genuine emotional vocalizations, be they heartfelt distress cries or raucous laughter. Here, we present perceptual ratings and a description of a freely available, large database of natural affective vocal sounds from human infants, adults and domestic animals, the Oxford Vocal (OxVoc) Sounds database. This database consists of 173 non-verbal sounds expressing a range of happy, sad, and neutral emotional states. Ratings are presented for the sounds on a (...) range of dimensions from a number of independent participant samples. Perceptions related to valence, including distress, vocalizer mood, and listener mood are presented in Study 1. Perceptions of the arousal of the sound, listener motivation to respond and valence (positive, negative) are presented in Study 2. Perceptions of the emotional content of the stimuli in both Study 1 and 2 were consistent with the predefined categories (e.g., laugh stimuli perceived as positive). While the adult vocalizations received more extreme valence ratings, rated motivation to respond to the sounds was highest for the infant sounds. The major advantages of this database are the inclusion of vocalizations from naturalistic situations, which represent genuine expressions of emotion, and the inclusion of vocalizations from animals and infants, providing comparison stimuli for use in cross-species and developmental studies. The associated website provides a detailed description of the physical properties of each sound stimulus along with cross-category descriptions. (shrink)

Anhedonia is a risk factor for suicide and poor treatment response in depressed individuals. Most evidence-based psychological therapies target symptoms of heightened negative affect instead of deficits in positive affect and typically show little benefit for anhedonia. Viewing positive scenes through virtual reality has been shown to increase positive affect and holds great promise for addressing anhedonic symptoms. In this pilot study, six participants with clinically significant depression completed 13 sessions of exposure to positive scenes in a controlled VR environment. (...) Significant decreases were found in self-reported anhedonia, depression, anxiety, and impairments in functioning from baseline to 1-month follow-up. Negative affect decreased over all 13 sessions, and positive affect increased over sessions 8–13. Results suggest that positive experiences in VR may be a novel avenue for the treatment of anhedonia in depressed individuals. (shrink)

Recent research indicates that angry facial expressions are preferentially processed and may facilitate automatic avoidance response, especially in socially anxious individuals. However, few studies have examined whether this bias also expresses itself in more complex cognitive processes and behavior such as decision making. We recently introduced a variation of the Iowa Gambling Task which allowed us to document the influence of task-irrelevant emotional cues on rational decision making. The present study used a modified gambling task to investigate the impact of (...) angry facial expressions on decision making in 38 individuals with a wide range of social anxiety. Participants were to find out which choices were (dis-) advantageous to maximize overall gain. To create a decision conflict between approach of reward and avoidance of fear-relevant angry faces, advantageous choices were associated with angry facial expressions, whereas disadvantageous choices were associated with happy facial expressions. Results indicated that higher social avoidance predicted less advantageous decisions in the beginning of the task, i.e., when contingencies were still uncertain. Interactions with specific skin conductance responses further clarified that this initial avoidance only occurred in combination with elevated responses before choosing an angry facial expressions. In addition, an interaction between high trait anxiety and elevated responses to early losses predicted faster learning of an advantageous strategy. These effects were independent of intelligence, general risky decision-making, self-reported state anxiety, and depression. Thus, socially avoidant individuals who respond emotionally to angry facial expressions are more likely to show avoidance of these faces under uncertainty. This novel laboratory paradigm may be an appropriate analog for central features of social anxiety. (shrink)

This study examined within-person co-occurrence of self-focus, negative affect, and stress in a community sample of adolescents with or without emotional disorders. As part of a larger study, 278 adolescents were interviewed about emotional disorders. Later, they completed diary measures over three days, six times a day, reporting their current thoughts, affect, and levels of stress. Negative affect was independently related to both concurrent stress and self-focus. Importantly, the association between negative affect and self-focus was stronger among participants with a (...) recent unipolar mood disorder, compared to those with an anxiety disorder, comorbid anxiety and depression, or those without an emotional disorder. The implications of these findings to theories of self-focus and its role in emotional disorders are discussed. (shrink)

Jan G. Michel klärt in seinem Artikel "Vom Transhumanismus zur These des erweiterten Geistes: Ethische Implikationen?" zunächst eine eindeutige These des Transhumanismus, den er als die Position versteht, dass menschliche Personen ihre gegenwärtigen physischen und mentalen Limitationen durch die von den Wissenschaften zur Verfügung gestellten Technologien erweitern können. Im Anschluss daran wendet er sich der in der Philosophie des Geistes und der Kognitionswissenschaft diskutierten sogenannten These des erweiterten Geistes zu und argumentiert, dass entgegen des ersten Eindrucks der für diese Debatte (...) zentrale Begriff nicht derjenige des menschlichen Geistes, sondern der Begriff der Kognition ist, die sich aus Sicht Michels durch externe, technologische Hilfsmittel erweitern lässt, ohne dass dadurch gravierende ethische Implikationen für den Personenstatus impliziert werden. Michel endet mit einer Analyse des für den Transhumanismus oft als zentral angenommenen Begriffs der erweiterten Person und fragt kritisch nach dem semantischen Gehalt dieses Begriffs. (shrink)

Jan G. Michel argues that we need a philosophy of scientific discovery. Before turning to the question of what such a philosophy might look like, he addresses two questions: Don’t we have a philosophy of scientific discovery yet? And do we need one at all? To answer the first question, he takes a closer look at history and finds that we have not had a systematic philosophy of scientific discovery worthy of the name for over 150 years. To answer the (...) second question, Michel puts forward three arguments that show the importance of a philosophy of scientific discovery. Briefly, he arrives at the following answers: No, we don’t yet have a philosophy of scientific discovery, and yes, we definitely need one. To remedy this shortcoming, Michel analyzes the concept of discovery, leading him to the insight that scientific discoveries have an underlying structure with certain structural features. Some of these features may be important but not indispensable to scientific discovery processes; these include eureka moments, serendipities, joint discoveries, special science funding, and others. In addition, Michel identifies three indispensable structural features which he examines in detail and which he places in a picture with a certain dynamics according to which the process of making scientific discoveries can be seen as a path, leading us from finding and acceptance to knowledge. (shrink)

BackgroundPalliative sedation and analgesia are employed in patients with refractory and intractable symptoms at the end of life to reduce their suffering by lowering their level of consciousness. The doctrine of double effect, a philosophical principle that justifies doing a “good action” with a potentially “bad effect,” is frequently employed to provide an ethical justification for this practice. Main textWe argue that palliative sedation and analgesia do not fulfill the conditions required to apply the doctrine of double effect, and therefore (...) its use in this domain is inappropriate. Furthermore, we argue that the frequent application of the doctrine of double effect to palliative sedation and analgesia reflects physicians’ discomfort with the complex moral, intentional, and causal aspects of end-of-life care. ConclusionsWe are concerned that this misapplication of the doctrine of double effect can consequently impair physicians’ ethical reasoning and relationships with patients at the end of life. (shrink)

Researchers in science and technology studies appear to be more concerned with descriptions and explanations of social phenomena than with the potential applications of their findings. Science and technology studies should strive to change society by contributing to the design of learning environments that form future generations of producers and consumers of scientific and technological knowledge. In this article, the authors illustrate how they used research findings from science and technology studies to design alternative learning environments and summarize their principal (...) findings from six years of ethnographic research in these learning environments. They conclude by pointing out some of the caveats inherent in theirapproach and by suggesting areas in science education of interest to science and technology studies. (shrink)

John Searle zählt zweifellos zu den weltweit wichtigsten und einflussreichsten Denkern der Gegenwart. Seine grundlegenden und nachhaltigen Beiträge zur Sprachphilosophie, zur Philosophie des Geistes, zur Handlungstheorie und zur Sozialphilosophie werden weit über die Grenzen des Fachs Philosophie hinaus wahrgenommen und gehören vielfach zum Standardrepertoire wissenschaftlicher Forschung und Lehre. -/- Michael Kober und Jan G. Michel bieten in diesem Buch eine übersichtliche sowie gut verständliche, aber auch kritische Einführung in das Gesamtwerk John Searles: Neben einer sehr persönlichen biographischen Notiz und einem (...) kurzen Überblick über seine Leitfragen und Positionen wird jeder der genannten Arbeitsbereiche John Searles in seinen wesentlichen Grundzügen historisch wie systematisch eingeordnet, dargestellt und diskutiert. Indem Kober und Michel dabei nicht chronologisch, sondern inhaltlich systematisch vorgehen, treten außerdem die Zusammenhänge innerhalb des Gesamtwerks John Searles deutlich hervor, so dass dieses schließlich im Lichte der heutigen Philosophie bewertet werden kann. (shrink)

Zu den großen Rätseln der Philosophie des Geistes, ja der Philosophie überhaupt, gehört die folgende Frage: Wie lässt sich der qualitative oder phänomenale Charakter bewusster Erlebnisse beschreiben, erklären oder verstehen? Wie lässt sich beispielsweise erklären, wie es ist, eine Rose zu riechen? Einerseits erscheint angesichts der Erfolgsgeschichte der modernen Naturwissenschaften die Annahme plausibel, dass sich letztlich alles physikalisch erklären lässt, auch bewusste Erlebnisse. Bei dieser Annahme handelt es sich um die physikalistische Intuition, die in der analytischen Philosophie des Geistes die (...) Hauptmotivation der gegenwärtig dominierenden Position darstellt: der Position des Physikalismus. Andererseits stellt der nur subjektiv erfassbare qualitative Charakter bewusster Erlebnisse das Kernproblem für eine physikalische Erklärung des Bewusstseins dar: Wie sollte das Erlebnis von Rosenduft physikalisch erklärbar sein? Dabei handelt es sich um die antiphysikalistische Intuition, auf deren Grundlage in den letzten Jahren verschiedene Argumente gegen den Physikalismus vorgebracht worden sind. Indem in der vorliegenden Studie diesen beiden, zumindest auf den ersten Blick unvereinbar erscheinenden Intuitionen ausführlich und vorbehaltlos Rechnung getragen wird – sie stellen sowohl den Ausgangspunkt als auch den argumentativen Rahmen der Studie dar –, wird untersucht, wie sich der qualitative Charakter bewusster Erlebnisse im Rahmen einer Theorie des Bewusstseins fassen lässt. (shrink)

Scientific progress depends crucially on scientific discoveries. Yet the topic of scientific discoveries has not been central to debate in the philosophy of science. This book aims to remedy this shortcoming. Based on a broad reading of the term “science” (similar to the German term “Wissenschaft”), the book convenes experts from different disciplines who reflect upon several intertwined questions connected to the topic of making scientific discoveries. -/- Among these questions are the following: What are the preconditions for making scientific (...) discoveries? What is it that we (have to) do when we make discoveries in science? What are the objects of scientific discoveries, how do we name them, and how do scientific names function? Do discoveries in, say, physics and biology, share an underlying structure, or do they differ from each other in crucial ways? Are other fields such as theology and environmental studies loci of scientific discovery? What is the purpose of making scientific discoveries? Explaining nature or reality? Increasing scientific knowledge? Finding new truths? If so, how can we account for instructive blunders and serendipities in science? -/- In the light of the above, the following is an encompassing question of the book: What does it mean to make a discovery in science, and how can scientific discoveries be distinguished from non-scientific discoveries? (shrink)

The focus of this article is a question that has been neglected in debates about digitalization: Could machines replace human scientists? To provide an intelligible answer to it, we need to answer a further question: What is it that makes (or constitutes) a scientist? I offer an answer to this question by proposing a new demarcation criterion for science which I call “the discoverability criterion”. I proceed as follows: (1) I explain why the target question of this article is important, (...) and (2) show that it leads to a variant of the demarcation problem of science. (3) By arguing that it is probably an essential feature of science that we can make scientific discoveries, I suggest a novel way of dealing with this problem by proposing a new demarcation criterion. Before introducing it, (4) I analyze an exemplary case of a real scientific discovery, and (5) argue that scientific discovery processes have a general underlying structure. (6) I introduce my discoverability criterion for science and present my master argument that helps us understand which criteria have to be fulfilled in order to decide whether machines can replace human scientists or not. (7) I conclude by answering the article’s target question and bringing forward a take-home message. (shrink)

The aim of this paper is twofold: The general aim is to shed light on the structure of species discoveries new to biology by bringing together a practice-oriented philosophy of science perspective with a philosophy of language perspective. The more specific aim is to argue that and to show how the overall structure of biological species discoveries comprises aspects of both institutional and non-institutional reality. The author proceeds as follows: he shows that placing the focus on the topic of scientific (...) discoveries enables us to circumvent two long-standing problems. He analyzes three fictional cases of discoveries in order to bring about a greater sensitivity for the concept of discovery. He takes a closer look at a real example – the discovery of a deep-sea anglerfish – and identifies the main structural features of species discovery processes in biology. In order to connect these results with Searle’s account of institutional reality, he provides an overview of the conceptual apparatus needed here. In bringing Searle’s account together with the structural features of species discoveries developed before, he shows to what extent declarative speech acts play a central role in species discovery processes in biology. (shrink)

Abstract:Facial transplantation is emerging as a therapeutic option for self-inflicted gunshot wounds. The self-inflicted nature of this injury raises questions about the appropriate role of self-harm in determining patient eligibility. Potential candidates for facial transplantation undergo extensive psychosocial screening. The presence of a self-inflicted gunshot wound warrants special attention to ensure that a patient is prepared to undergo a demanding procedure that poses significant risk, as well as stringent lifelong management. Herein, we explore the ethics of considering mechanism of injury (...) in the patient selection process, referring to the precedent set forth in solid organ transplantation. We also consider the available evidence regarding outcomes of individuals transplanted for self-inflicted mechanisms of injury in both solid organ and facial transplantation. We conclude that while the presence of a self-inflicted gunshot wound is significant in the overall evaluation of the candidate, it does not on its own warrant exclusion from consideration for a facial transplantation. (shrink)

The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental fndings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental fndings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and limits of (...) this professional obligation to respond to incidental fndings, bearing in mind that the relationship between investigators and research participants differs fundamentally from the doctor-patient relationship. (shrink)